Endocrine Abstracts

Osteoporosis is considered to be a cardinal feature of Cushing's syndrome with a reported incidence as high as 90%. We conducted a cross-sectional analysis of baseline bone mineral density (BMD) in 21 patients (4 males) aged 19-63 (median, 37) years with untreated Cushing's syndrome. 18 patients had pituitary dependent disease and 3 adrenal adenomas. Dual energy x-ray absorptiometry (DEXA) was used to measure the BMD at the lumbar spine (L1-L4), left femoral neck (LFN) and tot...

Introduction: Increased capacity for glucocorticoid regeneration in subcutaneous adipose tissue (SAT) by 11β-hydroxysteroid dehydrogenase-1 (11HSD1) is associated with obesity and associated risk factors. We hypothesised that down-regulation of SAT 11HSD1 and/or glucocorticoid receptor-α (GRα) may explain differences in body fat distribution and metabolic risk between black and white women. The study aimed to compare the expression of 11HSD1 and glucocorticoid r...